Microvascular dysfunction following cardioplegic arrest and cardiopulmonary bypass
نویسندگان
چکیده
Vessel Plus is an open acccess journal, which publishes articles related to vascular diseases, including acute respiratory distress syndrome, aneurysm, atherosclerosis, hypertension, stroke, peripheral or pulmonary etc.
منابع مشابه
Prevention of TNFalpha-associated myocardial dysfunction resulting from cardiopulmonary bypass and cardioplegic arrest by glucocorticoid treatment.
OBJECTIVE Cardiac surgery on cardiopulmonary bypass (CPB) results in progressive myocardial dysfunction, despite unimpaired coronary blood flow, and is associated with increased myocardial tumor necrosis factor-alpha (TNFalpha) expression. We investigated whether anti-inflammatory treatment prevents increased TNFalpha expression and myocardial dysfunction after CPB. METHODS AND RESULTS Baseli...
متن کاملDifferences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest.
BACKGROUND Diabetes mellitus is an independent risk factor for early postoperative mortality and complications after coronary artery bypass grafting (CABG). We sought to compare the cardiac gene expression responses to cardiopulmonary bypass (CPB) and cardioplegic arrest (C) in patients with and without diabetes. METHODS AND RESULTS Twenty atrial myocardium samples were harvested from 5 type ...
متن کاملImproved myocardial function using a Na+/H+ exchanger inhibitor during cardioplegic arrest and cardiopulmonary bypass.
INTRODUCTION We have demonstrated that a component of post-cardiopulmonary bypass (CPB)/cardioplegic arrest (CPA) myocardial dysfunction is related to myocardial edema. Myocardial ischemia/reperfusion that occurs with CPB/CPA activates the Na(+)/H(+) exchanger to normalize intracellular pH, with intracellular Na(+) (and water) accumulation. We hypothesized that Na(+)/H(+) exchanger inhibition w...
متن کاملA novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper
BACKGROUND Given the growing population of cardiac surgery patients with impaired preoperative cardiac function and rapidly expanding surgical techniques, continued efforts to improve myocardial protection strategies are warranted. Prior research is mostly limited to either large animal models or ex vivo preparations. We developed a new in vivo survival model that combines administration of ant...
متن کاملCytokine responses to myocardial revascularization on cardiopulmonary bypass: intermittent crossclamping versus blood cardioplegic arrest.
BACKGROUND The inflammatory responses to the different myocardial protection approaches have not been thoroughly investigated. We sought to study the cytokine responses to cardiopulmonary bypass (CPB) using the intermittent aortic crossclamping with ventricular fibrillation (IAC) versus blood cardioplegic arrest (BC) techniques. METHODS Perioperative plasma levels of tumor necrosis factor a (...
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ژورنال
عنوان ژورنال: Vessel plus
سال: 2021
ISSN: ['2574-1209']
DOI: https://doi.org/10.20517/2574-1209.2021.57